Target Explorer

Enter a pair of Rv numbers and select expression profiles below to compute correlation plots

Map Gene Expression Profiles Onto Kegg Pathways

Descriptive Features

select	constraint	weight	treatment of raw data	(override weighted sorting)
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Rv Number
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Gene Name
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Annotation
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Membrane
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Signal Peptide
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Operon Name
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Functional Category
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Kegg Pathway
				No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	PDB code
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Length

Target Prioritization Features from Hasan et al. (2006)

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	LipinskiDruggable
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	ECDruggable
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	UniqueProduct
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	UniqueSubstrate
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	UniqueEC
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	pdb_structure
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	smid_domain
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	PhysicalProperties
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Phylogeny
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	PLOS_Rank

Essentiality Data from various sources

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	TRASH_in_vitro
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Original_TRASH_in_vitro
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Original_TRASH_in_vivo
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	TRASH_combined
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	DEADMAN_essential
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	isolate_deletion

Existence of Homologs in other Species

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	M_leprae
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	C_glutamicum
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	M_E_coli
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Human

Data from Microarray Experiments collected by Hasan et al. (2006)

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	M0_ACT_48
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	M0_ACT_OLIGO_24
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	M0_NAIVE_48
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	M0_NAIVE_OLIGO
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	starvation_6
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	boshoff_starvation_6
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	betts_starvation_96
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	nrp1_2
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	boshoff_nrp1_aerobic
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	boshoff_nrp1_log_2
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	hypoxia_1
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	nrp2
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Boshoff_pH4_8
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Boshoff_pH5_2
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Boshoff_pH5_6

Data from Microarray Experiments conducted by Voskuil et al. (2004)

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_0
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_6
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_8
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_14
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_24
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_60
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_4_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_6_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_8_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_10_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_12_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_14_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_20_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_30_NRP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Vosk_Day_80_NRP

Data from Microarray Experiments conducted by Schnappinger et al. (2003)

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Naive_Macrophage_4hrs
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Naive_Macrophage_24hrs
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Naive_Macrophage_24hrs_oligo
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Naive_Macrophage_48hrs
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Activated_Macrophage_4hrs
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Activated_Macrophage_24hrs
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Activated_Macrophage_24hrs_oligo
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Activated_Macrophage_48hrs

Regulation profiles of genes during nutrient starvation (experiments conducted by Betts et al; 2002)

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Betts Starvation (4 hrs)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Betts Starvation (24 hrs)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Betts Starvation (96 hrs)

Micro-array data: Response to Drug Treatments (H. Boshoff)

select	constraint	weight	treatment of raw data	(override weighted sorting)
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_109
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_124196
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_111895
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_111891
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_121940
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_241
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	D_59
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	5CL_PZA
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	ARP4
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Amikacin
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Amp
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Antimycin
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Ascididemin_Nat_prod
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	BZA
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	CCCP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	CPZ
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Cap
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Cephalexin
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Cerulenin
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Clofazimine
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Clotrimazole
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	DIPED
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	DCCD
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	DNP
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Dipyridyl
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	DTNB
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	DTT
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Deferoxamine
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	EMB
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Econazole
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	Eta
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	GSNO
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	GSNO_CFZ
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	GSNO_CPZ
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	GSNO_KCN
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	GSNO_menadione
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	H2O2
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	INH
			no normalization standard normalization range normalization	No sort Primary Key: ascending Primary Key: descending Secondary Key: ascending Secondary Key: descending	KCN